Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to ageing

October 2017

Research

Country of origin: Germany

Mesencephalic dopamine (DA) projections are essential for cognitive and behavioural functions and believed to play a critical role during development and ageing. Researchers have concluded that he dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and ageing of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.

The complete article is available online.

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